Endometriosis is a common gynecological condition in which tissue similar to the tissue normally found lining the inside of the uterus is found on the outside of the uterus. This tissue outside the uterus acts the same as it normally would in the uterus by thickening, being released, and bleeding when you have your menstrual cycle.
This causes pain and inflammation and can lead to complications such as ovarian cysts , scarring, irritation, and infertility. Lupron Depot is a prescription medication that is injected into the body every month or every 3 months to help reduce endometriosis pain and complications. Lupron works by reducing the overall levels of estrogen in the body. Estrogen is what causes the tissues inside the uterus to grow.
When you first begin treatment with Lupron, the estrogen levels in your body increase for 1 or 2 weeks. Some women experience a worsening of their symptoms during this time. After a few weeks, your estrogen levels will decrease, stopping ovulation and your period. At this point, you should experience relief from your endometriosis pain and symptoms. Lupron has been found to reduce endometrial pain in the pelvis and abdomen. Doctors discovered that women taking Lupron decreased signs and symptoms for patients with endometriosis after monthly treatment when taken for 6 months.
Additionally, Lupron has been found to reduce pain during sexual intercourse when taken for at least 6 months. According to researchers, its efficacy is similar to that of danazol , a testosterone medication that can also reduce estrogen in the body to ease endometrial pain and symptoms. Danazol is rarely used today because it has been found to cause many unpleasant side effects, such as increased body hair, acne, and weight gain.
Lupron is considered a gonadotropin-releasing hormone Gn-RH agonist because it blocks production of estrogen in the body to reduce endometriosis symptoms. Without protection, you may become pregnant on Lupron. To avoid drug interactions and potential pregnancy, use nonhormonal methods of birth control such as condoms, a diaphragm, or a copper IUD.
Lupron is commonly used during fertility treatments such as in vitro fertilization IVF. Your doctor may have you take it to prevent ovulation before harvesting eggs from your body for fertilization. Lupron can also be used to increase the efficacy of certain fertility drugs.
What is Lupron Depot and how does it work? Lupron Depot can treat: Endometriosis Treatment lasts for 6 months. Uterine fibroids Treatment lasts up to 3 months. Pelvic pain Your health care provider will tell you how long you will keep getting these shots.
How is Lupron Depot used? It is given by injection shots. The shots are given in the hip. This depends on the dose. How well does Lupron Depot work? They may go back to their original size within a couple years after going off Lupron Depot unless menopause happens by then. How much does Lupron Depot cost? Pros After a few months of therapy, your periods should stop. It can be used with iron to improve anemia due to heavy periods because of fibroids.
It can be used to relieve symptoms of endometriosis. It helps to stop irregular menstrual bleeding. Many women who have endometriosis initially go to their doctors because of chronic pelvic pain.
Your doctor may initially prescribe medications such as contraceptives OCs or nonsteroidal anti-inflammatory drugs NSAIDs to treat that pelvic pain after ruling out other causes, such as infections. It can help relieve the pain of endometriosis and reduce endometriotic lesions. Suppressing the hormones helps 1,4 :. For illustrative purposes only.
Responses may vary in individual patients. During this time, you may notice an increase in your current symptoms. Even though you may not have a period, unprotected intercourse could result in pregnancy.
You should use non-hormonal birth control such as condoms, a diaphragm with contraceptive jelly, or a copper IUD to prevent pregnancy. Contact your doctor immediately if you think you may be pregnant. Many also experienced relief from painful intercourse, pelvic tenderness, and pelvic pain.
One hundred and twenty-five patients from two 6-month, double-blind, randomized clinical studies entered a 1-year follow-up study. This study grouped patients who received 3. The primary endometriosis signs and symptoms assessed were dysmenorrhea painful periods , non-menstrual pelvic pain NMPP pain in the pelvic area before or after periods , dyspareunia pain during sex , pelvic tenderness pain during the pelvic examination , and induration hardening of pelvic tissues.
The first day of the study was considered to be 29 days after the final study injection. Return of pain was defined to have occurred during the month for which pain levels returned to baseline prior to treatment levels or worse. At each study visit, an evaluation was made of dysmenorrhea, NMPP, and dyspareunia by patient interview. Pelvic tenderness and induration were evaluated by pelvic examination.
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Click here for Full Prescribing Information for Lupaneta Pack leuprolide acetate for depot suspension and norethindrone acetate tablets. Understanding Endometriosis Learn more about endometriosis, its common symptoms, and how it is treated. Where can endometriosis occur?
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